Ostarine or MK2866is the SARM that is being developed for the prevention and treatment of muscle wasting. It is currently undergoing clinical trials and may eventually be the medical prescription for prevention of cachexia, atrophy and sarcopenia.
As a research compound, Ostarine (MK-2866) belongs to a class of chemicals known Selective Androgen Receptor Modulators (SARMs). SARMs create selective anabolic activity at certain androgen receptors and not others, hence their name. Compared to pro hormones, testosterone and other anabolic androgenic steroids, the advantage of SARMs like Ostarine are that they do not have androgenic activity in non-skeletal-muscle tissues.
How does Ostarine work?
Selective androgen receptor modulators (SARMs) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity. By binding at certain androgen receptors, SARMs activate the androgen receptor and alters the expression of the gene involved in increasing muscle protein synthesis (building muscle). So in essence, SARMs such as Ostarine causes muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids and prohormones, SARMs (as non steroidal agents) do not promote prostate or other secondary sexual organ growth.
Ostarine in particular exerts its anabolic effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions such as muscle wasting diseases (from age-related to AIDS or cancer-related), but is also possesses immense potential for muscle building for Bodybuilders, fitness, athletes to maximise muscle building and minimize atrophy during recovery periods from injury.
Do I need a PCT with Ostarine MK-2866?
In comparison to anabolic steroids, Ostarine does not shutdown endogenous hormone production, therefore a PCT period is not needed and almost all the mass that is gained on Ostarine is kept once the cycle is finished.
Doses of 20mg for 4-6 weeks are the most common protocol for such goals. Over this 4-6 week period will typically produce 6lbs or 3kg of retainable lean muscle gains. Some users, however, have used doses up to 36mg per week, albeit this is only recommended for those who weigh 210lbs (95kg)+ for periods as long as 8 weeks. The potential for suppression from such doses is higher and users should consider using a natural PCT protocol (NVRENUF THOR) proceeding the end of their cycle.
Losing Body fat (cutting) with Ostarine MK2866.
Ostarine would primarily fit into a cutting protocol for the maintenance of muscle mass whilst reducing calories. One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue. As Ostarine has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss. Ostarine has also shown noticeable nutrient partitioning effects among users, another reason why it can be of great help when cutting. A 10-20mg dosing protocol for 4-6 weeks is good for cutting with Ostarine without undergoing any side effects or suppression.
Recomping with MK-2866 Ostarine.
Recomping is gaining muscle and losing body fat at the same time. This, in our opinion, is where Ostarine really shines. The body recomposition effect of losing fat and gaining muscle at the same time is what the majority of users are looking for. In the absence of SARMs, trying to achieve this when you are not absolutely new to training is extremely difficult. Ostarine is well known for its nutrient partitioning benefits. Fat stores alongside calories consumed through whole foods are utilised to support the growth of new muscle tissue. In fact, many users report that Osta consumed at maintenance calories induces fat loss, whilst still getting increases in strength and muscle mass! One of the most important factors to recomping however is allowing sufficient TIME for it to take place.
Although Osta is taken orally, as it is not methylated it is not as liver toxic as other oral steroids/pro-hormones.Ostarinecan be run for longer than the standard 4 week period with the aforementioned compounds. The dosing protocol of 10-20mg per day for 4-8 weeks will give excellent recomp effects. It should be noted however, users diet must also be optimised whereby calories are just above maintenance with at least 30% coming from lean sources of protein to get the best recomp effect.
Timing of Doses of Ostarine MK2866
As Ostarine has a half life of around 24 hours, each of these dosages should be taken orally once a day, therefore it offers an extremely convenient supplementation intake.
Ostarine and estrogen concern
SARMs cannot be aromatised, conferring all their effects to the androgen receptors binding and not to metabolic conversion to active androgens/oestrogen's. However, blood work from users has shown a slight elevation in serum estradiol levels (which may be one of the factors in its high effectiveness for treating tendon, ligament, and bone injuries or illnesses. This elevation is extremely small and is no case for concern. If however you are concerned about slight increases in Estrogen, you can always opt for low doses of over the counter PCTs such as THOR.